Abstract
Sublethal effects of insecticides on insects have been widely documented. However, the underlining mechanisms remain largely unclear. Insecticides may be as ligands and disruptors to affect the expression and function of tyrosine kinase receptors (RTKs). Based on the transcriptome and the genomic data of Leptinotarsa decemlineata, 15 novel RTK members were identified and annotated in the present paper. These RTKs showed distinct 1:1 orthology relationships with Tribolium castaneum ones, suggesting functional conservation of RTKs in insects. The expression responses of the 16 RTKs to sublethal exposure to two juvenile hormone analogs (methoprene and pyriproxyfen) and three γ-aminobutyric acid receptor blockers (fipronil, butene-fipronil and endosulfan) were determined. Each of the 5 insecticides changed the expression levels of a specific subset of RTK genes, demonstrating that RTK genes respond transcriptionally to insecticides by a mode-of-action independent way. Our results raise the possibilities that insecticides may exert their sublethal effects through affecting the expression of RTK genes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
