Abstract
The transforrnation of the native (4S) uterine cytosol-receptor complex to an active (5S) form is an estrogen-requiring, temperature-dependent process, the rate of which is affected by the pH and ionic strength of the cytosol. Unlike its 4S precursor, the transformed complex is retained by uterine nuclei and chromatin but by non-target tissue chromatin as well. The specificity of the in vitro nuclear uptake of transformed receptor complex appears to reside in the biochemical response; transformed receptor effects in vitro the same target tissue specific, quantitative stimulation and qualitative change in nuclear RNA synthesis as that observed in the target tissue after administration of the hormone in vivo.
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