Receptor Synergy From Thin Fiber Muscle Afferents. Focus on “Dorsal Root Ganglion Neurons Innervating Skeletal Muscle Respond to Physiological Combinations of Protons, ATP, and Lactate Mediated by ASIC, P2X, and TRPV1”

Abstract

In the recent article by Light et al., the authors identify the substances critical to signaling pain and fatigue in skeletal muscle. The identified substances act on Group III and IV fibers, which are thinly myelinated and unmyelinated, respectively, and correspond to their better known cutaneous