Abstract
1. In vitro methods for assessing melanin dispersion in melanophores are described, in which split fin preparations of the guppy, Lebistes reticulatus, were employed. 2. Acetylcholine and some current neurotransmitter suspects were ineffective in dispersing the pigment. 3. While exhibiting a melanin-aggregating action in higher concentrations, sympathomimetic monoamines in lower concentrations were found to disperse melanosomes. Such an action was more noticeable with beta stimulating drugs, some of them being solely pigment-dispersing. 4. These monoamine-induced dispersion responses were antagonized by beta adrenergic blocking agents. 5. Beta adrenoceptors in the melanophore appear to take part in the melanosome dispersion response of the cell.
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