Abstract
Protein tyrosine phosphatase ζ (PTPζ)/RPTPβ is a chondroitin sulfate proteoglycan predominantly expressed in the brain. In this study, we examined immunohistochemical localisation of PTPζ in the mouse telencephalon from embryonic day 9.5 (E9.5) to E15.5. During E10.5–E12.5, immunoreactivities for PTPζ are specifically observed on the tangentially aligned neurons at the preplate (PP) of the neocortex, as well as on the neurons at the mantle layer (ML) of the ganglionic eminences (GEs). Likewise, neurons immunoreactive for CR50, a marker for Cajal–Retzius neurons, are aligned from the ML of the ganglionic eminences to the PP of the neocortex and co-express PTPζ. During E13.5–E15.5, PTPζ-positive neurons are present at the subplate (SP) as well as at the marginal zone (MZ) of the neocortex. These results indicate that PTPζ is a useful marker for early-generated neocortical neurons in mice: Cajal–Retzius neurons as well as the subplate neurons.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
