Abstract
Regeneration of the light sensitive visual pigment contained in the receptor outer segments apparently can account for only a portion of the sensitivity changes observed during dark adaptation (1, 2). The remaining sensitivity changes (the “neural” adaptation) take place even under conditions in which the bleached visual pigment does not undergo regeneration (3). In the past few years it has become increasingly evident that at least a portion of even “neural” adaptation occurs at the receptor level (4–9). In this work our aim was to demonstrate directly the existence of a receptor adaptation mechanism that is independent of visual pigment regeneration. We accomplished this by recording intracellularly from individual rods in the isolated retina of the axolotl (Ambystoma mexicanum) before and after bleaching varying amounts of the rod pigment (10). In our preparation no regeneration of the rod pigment could be detected in parallel spectrophotometric measurements (10).
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