Recent Updates and Advancement of Transdermal Drug Delivery System

Abstract

Tranderrmal drug delivery system is topically used drug administration’s which are mainly used in the form patch and the transdermal patch are applied on the skin. TDDS have better drug absorption, good bioavailability and the drug delivered through the skin in a systemic circulation by controlled drug delivery system. Today about 74% of drug are taken orally and that are less side effect, the drug are transported through the viable epidermis to dermis tissue of skin for the local therapeutic effect into the systemic circulation, TDDS avoids the first- pass metabolism , increased therapeutic effect and maintained the plasma drug level. In pharmaceutical industries have many new advancement of technology which modified all resources in TDDS, the drug used as a controlled drug delivery system but now days we used novel drug delivery system which is painless method of drug administration . The scientific development of transdermal patches were comes in 1970s and the first patches were approved in 1979 by FDA for the treatment of motion sickness. Now days, there are many numbers of patches exist in market such as fentanyl, nicotine, clonidine, nitroglycerine, oxybutinin, testosterone, lidnocaine and scopolamine. Along with, the transdermal drug delivery system (TDDS) represents many approaches. In this overview, we describe the different types of TDDS methods available and critically discuss their specific strengths and weaknesses, characterization methods, and the potential of each method. Advances in research on these alternative methods have demonstrated the high performance inherent in the TDDS, which are expected to find application in a wide range of applied.