Recent Trends of the Bio-Inspired Nanoparticles in Cancer Theranostics.

Vijay Sagar Madamsetty,Anubhab Mukherjee,Sudip Mukherjee

doi:10.3389/fphar.2019.01264

Vijay Sagar Madamsetty, Anubhab Mukherjee + Show 1 more

Open Access

https://doi.org/10.3389/fphar.2019.01264

Copy DOI

Abstract

In recent years, various nanomaterials have emerged as an exciting tool in cancer theranostic applications due to their multifunctional property and intrinsic molecular property aiding effective diagnosis, imaging, and successful therapy. However, chemically synthesized nanoparticles have several issues related to the cost, toxicity and effectiveness. In this context, bio-inspired nanoparticles (NPs) held edges over conventionally synthesized nanoparticles due to their low cost, easy synthesis and low toxicity. In this present review article, a detailed overview of the cancer theranostics applications of various bio-inspired has been provided. This includes the recent examples of liposomes, lipid nanoparticles, protein nanoparticles, inorganic nanoparticles, and viral nanoparticles. Finally, challenges and the future scopes of these NPs in cancer therapy and diagnostics applications are highlighted.

Highlights

In recent years, prodigious progress of nanotechnology prompted researchers across the globe to ponder over the enormous possibilities of commissioning this for developing imaging and diagnosticbased medicine for cancer
Multimodal theranostics nanomedicine has emerged as a providential paradigm in cancer therapy (Lammers et al, 2011; Kelkar and Reineke, 2011; Muthuraj et al, 2015; Muthuraj et al, 2016; Chowdhury et al, 2017)
It turns out that four crucial aspects exist to take into account while designing an efficient theranostic based nano-platform: i) Selecting an effective therapeutic agent, ii) to opt a stable carrier; iii) to implement a targeting and sustainable drug release approach; iv) to cautiously select an imaging agent (Mukherjee et al, 2014; Muthuraj et al, 2016; Chi et al, 2017; Chowdhury et al, 2017; Cong et al, 2018)

Summary

Introduction

Prodigious progress of nanotechnology prompted researchers across the globe to ponder over the enormous possibilities of commissioning this for developing imaging and diagnosticbased medicine for cancer. Biosynthesized multifunctional nanoparticles with noble metal centers encapsulating therapeutic and imaging agents were shown to possess theranostic activities against cancer (Duan et al, 2015; Ovais et al, 2018; Ma et al, 2018; Vemuri et al, 2019).

Results

Conclusion