Abstract
Abstract: Carbohydrates are complex and structurally diverse compounds in nature with key roles in a broad range of life processes, including signal transduction, carcinogenesis and immune responses. Many natural products contain oligosaccharides that are vital for their biological activity. However, the synthesis of complex oligosaccharides and other glycoconjugates is hampered by difficulties associated with the regioselective protection of polyhydroxyls and challenges related to the stereoselective assembly of glycosidic linkages. Therefore, a big challenge in glycochemistry is to have selectively protected monosaccharide units, one with a strategically positioned free hydroxy group (a nucleophilic acceptor for further glycosylation or functional-group modifications) and suitable protecting groups on the remaining hydroxyls.
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