Recent Trends in Leishmania Research: A Therapeutic Perspective

Junaid Jawed,Subrata Majumdar

doi:10.29245/2689-9981/2018/3.1120

Abstract

<p style="text-align: justify;">Leishmaniasis is a spectrum of disease caused by the infection of protozoan parasite Leishmania mainly affecting the antigen presenting cell of the host. The disease is although considered as neglected tropical disease still it is not completely eradicated. Majority of the issues related to the therapeutic approach is due to increased cytotoxicity of the drugs, less effectiveness, high cost and occurrence of drug resistance. Therefore, recent advancement in the field of parasitology has taken into consideration o

Highlights

Leishmaniasis is one of the world’s oldest recorded protozoan infectious diseases dating back to the 7th century BC, which is caused by the bite of infected sandfly during the course of their blood meal[1]
Leishmaniasis is of three basic types cutaneous, muco-cutaneous and visceral form based on the involvement of different species of Leishmania, among which Visceral Leishmaniasis (VL) is considered as the most fatal one as it affects visceral organ and if left untreated it often leads to death of the mammalian host[1]
Therapies are available for the cure of leishmaniasis including VL but most of these are associated with increased cyto-toxicity and showing

Summary

Introduction

Leishmaniasis is one of the world’s oldest recorded protozoan infectious diseases dating back to the 7th century BC, which is caused by the bite of infected sandfly during the course of their blood meal[1]. Sudden outbreak and the spread of the disease is associated with the changes in environmental conditions which is making more prone ambience for the growth of sand-fly vector, while the emigration of the people into the endemic areas are increasing the risk of mass individuals[3]. Increased drug resistance problems which is a major area of concern[5]. A serious concern is needed to find the way for the complete eradication of the disease which need government and private joint co-operation for the detail research in the field of leishmaniasis in order to find the effective solution for this problem. In this review we have highlighted the major therapeutic approach against leishmaniasis both past, present and the future strategies which is important to redefine the most safer, convenient and affordable way to fight against this deadly disease

Major Treatments Regime Against Leishmaniasis

Therapeutic approach with targeted drugs

Vaccine Against Leishmaniasis

Conclusion