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Abstract
Lipoxins (LXs) are endogenous lipid mediators that play a role on anti-inflammatory action, regulating immune response, and repairing damaged cells. It was also known as brake signal of inflammatory response. Researches revealed that LXs and aspirin-triggered lipoxin A4 (ATL) promote the macrophage cells and microglia cell phagocytose cell debris and apoptotic cells by different ways while it regulates anti-inflammation effect and stabilize internal milieu. We reviewed the research progresses in the study of LXs and phagocytosis and summarized their roles as four mechanisms: ① Changing cell polarity and rebuild cellular structure. ② Up-regulation of specific scavenger receptors. ③ Activating M2 phagocytes. ④ Inhibition the apoptosis of phagocytes. Microglia and its phagocytosis function play vital roles in brain diseases, thus studying LXs may provide new therapeutic strategies. Key words: Lipoxin; Inflammatory; Phagocytosis
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