Abstract
Leptin,an adipokine deriving mainly from adipose tissue,demonstrates pleiotropic effects.Recent studies show that it emerges as a significant factor in the regulation of bone metabolism.However,it is still controvesial of the relationship between leptin and bone mineral density (BMD)in clinical trials.Leptin can regulate bone metabolism by central pathways,peripheral pathways and sympathetic nervous system.In central pathways,serotonin,neuromedin U and neuropeptide Y are key mediators in the regulation of leptin on bone metabolism.In additon,the overall effect of leptin on bone metabolism might depend on serum leptin concentrations.The regulation of leptin on bone metabolism may provide a new direction for the treatment of osteoporosis. Key words: Leptin; Bone metabolism; Serotonin ; Sympathetic nervous system
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