Abstract
Biomarkers can be applied in early diagnosis and classification for the development and progression of diabetic kidney disease (DKD), and thus are very useful in improving patients' prognosis. According to current relevant guidelines, the early screening and staging of DKD is based both on the level of urinary albumin excretion and glomerular filtration rate (GFR). However, the sensitivity and specificity of microalbuminuria recently has been challenged, and high-normal level GFR is difficult to be accurately measured. Therefore, many researchers devote themselves to seek more appropriate biomarkers for DKD. This is a controversial issue with its pros and cons, involving in metabolism, inflammation, oxidation, stress, advanced glycation end products, fibrosis, endothelium function, tubular function, genetic background, podocyte injury, and so on.(Chin J Lab Med, 2015, 38: 583-585) Key words: Diabetic nephropathies; Biological markers
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