Recent Progress in the Synthesis of Quinolines

Abstract

New developments in the chemistry of quinoline derivatives are reviewed. Two general synthetic routes based on the utilization of mono-substituted or ortho-substituted anilines are discussed. Their major methods and modifications are analyzed. syntheses. These classical syntheses are well-known and still frequently used for the preparation of pharmaceutical agents, ligands and functional materials bearing a quinoline backbone. However, current methods for quinoline synthesis often do not allow for adequate diversity and substitution on the quinoline ring system (19). Recent developments in the chemistry of quinoline derivatives have demonstrated that new metal-catalyzed coupling cyclizations or acid catalyzed cycloaddition of appropriate precursors could compete with classical syntheses in the efficacy and rapidity of the quinoline construction. These new developments have prompted us to review and analyze their major methods and modifications.