Abstract
Abstract: In recent times, many research groups have focused their attention on nitrogencontaining heterocyclic compounds with the aim of gaining a deeper understanding of their biological characteristics. Among them, molecules based on 1,2,3-triazole and benzimidazole have exhibited diverse biological applications and are present in many drug molecules. The purpose of this review is to describe various benzimidazole-1,2,3-triazole hybrids and to provide a comprehensive evaluation of their biological properties. The compounds discussed in this study have been synthesized through a Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between diverse azides and alkynes, utilizing a 1,2,3-triazole scaffold as a linkage between two connecting groups. The synthesis of several benzimidazole-1,2,3- triazole hybrids is covered in this review, along with a biological assessment of their anticancer, antiproliferative, antitubercular, antibacterial, antidepressant, and other activities. Moreover, in our opinion, this review may be useful for the development of various medicinally significant molecules.
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