Abstract
AbstractThe influence of structural variations in compounds of the N‐acylalanine type, on their fungicidal activity towards Peronosporales, was examined. Within a series of methyl N‐(acyl)‐N‐(2,6‐xylyl)alaninates (I), a quantitative structure‐activity relationship was given for the curative action against Plasmopara viticola, through a Hansch‐type equation. A deviation from this equation is discussed with reference to benalaxyl (I; acyl=phenylacetyl). Syntheses and qualitative indications of activity are reported for structural changes in the xylyl and in the alanine moieties. Progress in the latter approach is briefly outlined.
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