Abstract
Inspired by molecular self-assembly, which is ubiquitous in natural environments and biological systems, self-assembled peptides have become a research hotspot in the biomedical field due to their inherent biocompatibility and biodegradability, properties that are afforded by the amide linkages forming the peptide backbone. This review summarizes the biological advantages, principles, and design strategies of self-assembled polypeptide systems. We then focus on the latest advances in in situ self-assembly of polypeptides in medical applications, such as oncotherapy, materials science, regenerative medicine, and drug delivery, and then briefly discuss their potential challenges in clinical treatment.
Highlights
Application of In Situ Self-AssembledPolypeptides are short chains composed of a number of amino acid monomers arranged in a specific order and bound by peptide bonds
The past five years have seen great strides in the synthesis of polypeptides with a number of approaches reported for obtaining controlled polypeptides from varied initiators in shorter timeframes, such as classical ring opening polymerization of α-amino acid, which plays an important role in the wide range of application [1,2,3]
We summarized the classification of self-assembled polypeptides and the main applications in oncotherapy, materials science, regenerative medicine, and drug delivery
Summary
Polypeptides are short chains composed of a number of amino acid monomers arranged in a specific order and bound by peptide bonds. The wrong folding of polypeptides into proteins will cause body disease, such as neurodegenerative diseases resulting from the fibrous assemblies of abnormal proteins [12] These phenomena have aroused great attention to the process of protein assembly, which clarified the cell function and disease mechanism to a certain extent and promoted the application of the biological functions of artificial nanostructured materials in biology and medicine. Inspired by these widespread principles in nature [13] (e.g., myoglobin, ferritin, nucleosome, collagen, double-strand DNA), scientists devoted themselves to utilize various biocompatible materials and more convenient synthetic methods, including aqueous. Schematic illustration of development of in vivo self-assembled polypeptides, including assembly driving forces, morphologies, bioeffects, and biomedical applications
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
