Recent progress in the Cu-catalyzed multicomponent synthesis of 1,4-disubstituted 1,2,3-triazoles

Abstract

1,2,3-Triazoles has emerged as one of the most important N-heterocyclic compounds with a broad range of pharmacological applications. This class of molecules can accommodate a wide range of substituents or groups around the core moiety that pave the mode for the synthesis of various bioactive compounds. Copper(I)-catalyzed azide-alkyne cycloaddition reaction has become one of the leading click chemistry methodologies due to its high biocompatibility, reliability, and specificity. 1,4-Disubstituted 1,2,3-triazoles synthesis via a multicomponent reaction has generated numerous compounds of biological interest in an efficient manner. This review summarizes the recent literature on the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles via copper-catalyzed multicomponent reactions since 2018.