Abstract
Recent progress in mucosal immunology and vaccine development
Highlights
Mucosal surfaces are covered with specialized epithelial cells that serve as physical barriers to the environment and prevent exogenous challenges by pathogens and soluble antigens.[1]
When antigens are administered with appropriate adjuvants or attenuated live vaccines via mucosal routes, the mucosal immune system can trigger both humoral and cell-mediated immune protection in mucosal sites and systemically.[2]
Knowledge of the molecular and cellular characteristics of M cells and mucosal dendritic cells (DCs) is fundamental for the design of mucosal vaccines, including considerations of delivery, adjuvant and formulation
Summary
Mucosal surfaces are covered with specialized epithelial cells that serve as physical barriers to the environment and prevent exogenous challenges by pathogens and soluble antigens.[1]. Mucosal surfaces are covered with specialized epithelial cells that serve as physical barriers to the environment and prevent exogenous challenges by pathogens and soluble antigens.[1] Functionally independent of the systemic immune compartments, the mucosal immune system has developed its own highly organized lymphoid tissues.
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