Recent Progress in Fluorescent Imaging Probes.

Yen Pak,Juyoung Yoon,K Swamy

doi:10.3390/s150924374

Abstract

Due to the simplicity and low detection limit, especially the bioimaging ability for cells, fluorescence probes serve as unique detection methods. With the aid of molecular recognition and specific organic reactions, research on fluorescent imaging probes has blossomed during the last decade. Especially, reaction based fluorescent probes have been proven to be highly selective for specific analytes. This review highlights our recent progress on fluorescent imaging probes for biologically important species, such as biothiols, reactive oxygen species, reactive nitrogen species, metal ions including Zn2+, Hg2+, Cu2+ and Au3+, and anions including cyanide and adenosine triphosphate (ATP).

Highlights

The recognition of biologically and environmentally important species in addition to imaging them has been an important research task in recent years [1,2,3]
The most dramatic change in this field was the appearance of reaction-based fluorescent probes, so-called chemodosimeters [18,19,20], which react with specific analytes, resulting in irreversible optical changes, yet, with usually better selectivity than those originating from host–guest chemistry
This review highlights the recent progress on fluorescent imaging probes for biologically important species, such as biothiols, reactive oxygen species, reactive nitrogen species, metal ions including Zn2+, Hg2+, Cu2+ and Au3+, and anions including cyanide and adenosine triphosphate (ATP)

Summary

Introduction

The recognition of biologically and environmentally important species in addition to imaging them has been an important research task in recent years [1,2,3]. Traditional approaches using molecular recognition and host–guest chemistry have been adopted to design fluorescent chemosensors for many years [14]. Earlier works on fluorescent chemosensors further extended their scopes for various biologically important analytes. The most dramatic change in this field was the appearance of reaction-based fluorescent probes, so-called chemodosimeters [18,19,20], which react with specific analytes, resulting in irreversible optical changes, yet, with usually better selectivity than those originating from host–guest chemistry. This review highlights the recent progress on fluorescent imaging probes for biologically important species, such as biothiols, reactive oxygen species, reactive nitrogen species, metal ions including Zn2+, Hg2+, Cu2+ and Au3+, and anions including cyanide and ATP

Fluorescent Probes for Biothiols

Fluorescent Imaging Probes for Metal Ions

10. Posterior neuromast

Fluorescent Imaging Probes for Cyanide and ATP

Findings

Conclusions and Future Perspectives