Abstract
Immunotherapy is a rapidly emerging approach to cancer therapy that focuses on empowering the immune system by countering the mechanisms whereby cancer cells frequently evade immunosurveillance and negate anticancer immune responses. However, there are major challenges to successful implementation of immunotherapy approaches in cancer treatment, mainly due to a lack of targetability and inefficient delivery of immunotherapeutics at the target site. The current review focuses on various anticancer immunotherapy approaches that have recently been investigated and employed, as well as on nanoparticle-based delivery techniques for immunotherapeutics that are being implemented as strategic approaches to overcome the limitations of cancer immunotherapy. Nanoparticle-based delivery techniques for immunotherapeutics have shown immense potential in effective targeting and efficient delivery of these agents at target sites, resulting in effective repression of the immune-evasive mechanisms employed by cancer cells, thereby significantly inducing immune-mediated cancer cell killing and inhibition of tumor proliferation and metastasis. Further understanding of cancer immunology and investigations into enhancing the specificity and targetability of nanoparticle delivery devices can lead to clinical success of nanoparticle-based immunotherapy approaches in cancer treatment.
Published Version
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