Abstract
Despite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and organs in the body. Controlling drug release at the target site, responding to stimuli that originated from internal changes within the body, as well as stimuli manipulated by external sources has recently received significant attention. Owning to the spherical shape and porous structure, dendrimer is utilized as a material for drug delivery. Moreover, the surface region of dendrimer has various moieties facilitating the surface functionalization to develop the desired material. Therefore, multi-stimuli-responsive dendrimers or ‘smart’ dendrimers that respond to more than two stimuli will be an inspired attempt to achieve the site-specific release and reduce as much as possible the side effects of the drug. The aim of this review was to delve much deeper into the recent progress of multi-stimuli-responsive dendrimers in the delivery of anticancer drugs in addition to the major potential challenges.
Highlights
Cancer has proven to be a significant liability when it comes to causing deaths globally and has risen as a noteworthy general medical issue
This review focuses on some of the available strategies on the synthesis of dendrimers that are capable of controlled drug release at the target site responding to stimuli that originated from internal changes within the body as well as physical stimuli manipulated by external sources
This review has demonstrated the application of various stimuli-responsive dendrimers in drug delivery, therapy, diagnosis, and tissue engineering
Summary
Cancer has proven to be a significant liability when it comes to causing deaths globally and has risen as a noteworthy general medical issue. PAMAM promise to create a great revolution in the field of medicine since they contain dendrimers characterized by a well-controlled structure These polymers have a lower critical temperature based on thermoresponsive. Due to their great structure and unique properties, dendrimers have proven their potential as better drug carriers. This review intends to examine the current developments in the use of multi-stimuli-responsive dendrimers as a drug administered for cancer treatment. This review focuses on some of the available strategies on the synthesis of dendrimers that are capable of controlled drug release at the target site responding to stimuli that originated from internal changes within the body as well as physical stimuli manipulated by external sources. The potential biomedical applications and promising research of multi-stimuli-responsive dendrimers are discussed
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