Abstract
Many bacteria, plants, and protozoa require the methylerythritol 4-phosphate (MEP) pathway to synthesize dimethylallyl diphosphate (DMADP) and isopentenyl diphosphate (IDP). DMADP and IDP are the universal precursors to isoprenoids which are essential to all living organisms. The MEP pathway is absent in humans; thus, the enzymes of this pathway are candidates for the development of herbicides and anti-infectives. Here, important advances in MEP pathway enzymology, structure, and inhibitor development from the past decade are reviewed. The authors’ outlooks on the future prospects of MEP pathway research are also described.
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