Recent insights into clinical COVID-19 causing novel human coronavirus

Abstract

As everyone on earth came is panic about recent pandemic about coronavirus disease 19 (COVID-19) which is the most transmissible, contagious, deadliest and pathogenic viral infection that is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China (Wuhan city). The genomic sequence alignment analysis confirmed the phylogenetic origin of SARSCoV-2 from severe acute respiratory syndrome-like (SARS-like). This outbreak is suspiciously originated as zoonotic from the bats which might be act as primary reservoir. But, the major source of origin reason for conversion of this virus as transmitting agent from zoonotic condition to human to humans is still unclear. However, this kind of human to human rapid transmission, the clear pathogenesis, ambiguity with its clinical manifestation, non availability of rapid diagnostic tools, and either lacking of clinically approved proper anti-COVID-19 drugs or non existence of preventive vaccine for SARS-CoV-1 is available till date. Hence, in this review, we are summarizing the basic nature of pathogenic COVID-19 virus, its source of origin, pathogenicity, life cycle, infection, immunological invade in the host, diagnosis, clinical manifestations, possible therapeutic approaches and preventive measures of novel human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) in comparison with middle east respiratory syndrome coronavirus (MERS-CoV).