Abstract
BackgroundRecent improvements in 5-year survival of breast cancer have been reported in Japan and other countries. Though the number of long-term breast cancer survivors has been increasing, recent improvements in 10-year survival have not been reported. Moreover, the degree of improvement according to age and disease stage remains unclear.MethodsWe calculated long-term survival using data on breast cancer diagnosed from 1993 through 2006 from six prefectural population-based cancer registries in Japan. The recent increase in 10-year relative survival was assessed by comparing the results of period analysis in 2002–2006 with the results of cohort analysis in 1993–1997. We also conducted stratified analyses by age group (15–34, 35–49, 50–69, and 70–99 years) and disease stage (localized, regional, and distant).ResultsA total of 63,348 patients were analysed. Ten-year relative survival improved by 2.4% (76.9% vs 79.3%) from 1993 through 2006. By age and stage, 10-year relative survival clearly improved in the age 35–49 years (+2.9%; 78.1% vs 81.0%), 50–69 years (+2.8%; 75.2% vs 78.0%) and regional disease (+3.4%; 64.9% vs 68.3%). In contrast, the degree of improvement was small in the age 15–34 years (+0.1%; 68.2% vs 68.3%), 70–99 years (+1.0%; 87.6% vs 88.6%), localized disease (+1.1%; 92.6% vs 93.7%) and distant metastasis (+0.9%; 13.8% vs 14.7%).ConclusionsThese population-based cancer registry data show that 10-year relative survival improved 2.4% over this period in Japan. By age and stage, improvement in the age 15–34 years and distant metastasis was very small, which suggests the need for new therapeutic strategies in these patients.
Highlights
Breast cancer is the most frequent female cancer in Japan, and the number of breast cancer patients continues to markedly increase
In population-based studies, 5-year relative survival (RS) have been usually calculated using cohort analysis, and improvements in the 5-year RS of breast cancer have reported in Japan.[3,4]
Most breast cancer patients survive more than 5 years, late recurrence from 5 years after diagnosis is still frequent.[8,9]
Summary
Breast cancer is the most frequent female cancer in Japan, and the number of breast cancer patients continues to markedly increase. Similar improvements have been observed in European countries and the United States,[5,6] with global surveillance of cancer survival from population-based registries showing a 5-year RS in 1995–1999 and 2005–2009 of 81.2% and 85.3% in Germany and 86.0% and 88.6% in the United States, respectively.[7] most breast cancer patients survive more than 5 years, late recurrence from 5 years after diagnosis is still frequent.[8,9] it is essential to evaluate improvements in longer-term survival, such as 10-year survival. Recent improvements in 5-year survival of breast cancer have been reported in Japan and other countries. Though the number of long-term breast cancer survivors has been increasing, recent improvements in 10-year survival have not been reported. The degree of improvement according to age and disease stage remains unclear
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