Abstract
This review highlights the recent formulation advances (different methods of preparation involving various novel approaches) that have been advancing the use of ODT as a popular dosage form. Furthermore, the important characteristics of ODTs that are required for patient compliance and appropriate therapeutic benefit are discussed. In addition to conventional ODTs, ODTs formulated for controlled release of pharmaceuticals and taste masking are also discussed.
Highlights
Disintegrating or orally dispersible tablets (ODTs) are dosage forms that disintegrate or dissolve rapidly on contact with saliva
After testing these ODTs in healthy human volunteers, the visual analog scales (VAS) scores of bitterness, numbness, and overall palatability were found to improve with organoleptic masking; it was concluded that the combined use of physical and organoleptic masking was useful for improving palatability of ODTs [46]
This study demonstrated that the presence of channels could accelerate the disintegration of ODTs because the channels could shorten the distance of water penetration and increased the specific surface area, resulting in a significant reduction in disintegration time
Summary
Disintegrating or orally dispersible tablets (ODTs) are dosage forms that disintegrate or dissolve rapidly on contact with saliva. Alyami et al have reported that among health care practitioners, ODTs are the second most popular choice for pediatric patients, with the first being liquids. They report that 63% of practitioners are in favor of substituting many liquid formulations with a suitable ODT [7]. The authors recommend that ODTs can be subdivided for dose adjustment purposes; one-half of the tablet would have to be discarded It has been suggested manufacturing method influences the suitability of ODTs for subdivision. It has been reported that, based on the currently available scientific evidence and the regulatory guidance, orally disintegrating dosage forms offer an innovative solution for pediatric drug delivery [11]
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