Abstract
Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.
Highlights
Recent Developments on Reactions with a single operational step involving three or more components are called multicomponent reactions (MCRs) [1,2,3,4]
Wang and co-workers developed a reaction for the synthesis of highly functionalized piperidines 40 using two equiv of aromatic aldehydes, and one equiv each of Meldrum’s acid, substituted β-nitrostyrenes and ammonium acetate under basic conditions
Mohammadpoor-Baltork and co-workers reported a method for the synthesis of biquinoline 58 employing two equiv of methyl propiolate and one equiv each of terephthaldialdehyde, naphthalen-1-amine, and p-toluidine using reusable Fe3O4-TDSN-Bi(III)
Summary
Recent Developments on Reactions with a single operational step involving three or more components are called multicomponent reactions (MCRs) [1,2,3,4]. They have inherent advantages of pot, atom, and step economy (PASE) in the formation of multiple bonds of complex molecules [5,6]. There are numerous monographs and review articles on 3CRs and 4 only two reviews related to 5CRs in 2013 and 2020 [9,11] Covered in this a mainly published after 2013.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
