Abstract
Wound therapy improves every year by developing new wound treatment options or by advancing already existing wound materials, for example, adding self-releasing analgesic drugs or growth factors to wound dressings, or by binding and inactivating excessive proteases. Also new dressing materials based on silk fibers and enhanced methods to reduce bacterial burden, for example, cold argon plasma, might help to fasten wound healing.
Highlights
Optimal modern wound dressings should assure a moisture wound bed, help drainage, remove debris of the wound surface, provide optimal thermal stability, might be removed without trauma of the wound bed and wound edge, and be antiallergenic and without immunogenicity
One alternative method to transfer endogenous growth factors to the wound area is the production of autologous platelet-rich fibrin (PRF) that is prepared from a simple blood sample of the patient and is a really low burden to the patient
While the deposition of Growth factors (GF) on the wound area from external sources like wound dressings or via PRF could so far not sustain its position within standard wound treatments, the focus extended to the observation that chronic wounds have raised levels of protease activity and any GF that are applied to the wound are often subjected to proteolytic degradation which renders them inactive
Summary
Optimal modern wound dressings should assure a moisture wound bed, help drainage, remove debris of the wound surface, provide optimal thermal stability, might be removed without trauma of the wound bed and wound edge, and be antiallergenic and without immunogenicity. Wound dressings are getting more and more functionalized to a targeted therapy by including different pharmaceutical compounds (e.g., antiseptics, analgetics, or growth factors). Those interactive additives might help optimize the healing process. We want to present an overview about some of those new developments in topical wound therapy (see Table 1)
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