Abstract
BackgroundCurrently one of the largest online repositories for human and mouse stem cell gene expression data, StemBase was first designed as a simple web-interface to DNA microarray data generated by the Canadian Stem Cell Network to facilitate the discovery of gene functions relevant to stem cell control and differentiation.FindingsSince its creation, StemBase has grown in both size and scope into a system with analysis tools that examine either the whole database at once, or slices of data, based on tissue type, cell type or gene of interest. As of September 1, 2008, StemBase contains gene expression data (microarray and Serial Analysis of Gene Expression) from 210 stem cell samples in 60 different experiments.ConclusionStemBase can be used to study gene expression in human and murine stem cells and is available at .
Highlights
One of the largest online repositories for human and mouse stem cell gene expression data, StemBase was first designed as a simple web-interface to DNA microarray data generated by the Canadian Stem Cell Network to facilitate the discovery of gene functions relevant to stem cell control and differentiation
To facilitate the discovery of genes with functions important to the control of stem cell fate, a collection of gene expression measurements in samples of stem cells and derivatives from mouse and human was produced. These data were generated within the framework of the Stem Cell Genomics Project and funded by the Canadian Stem Cell Network
The StemBase database was created as a public repository of these data
Summary
One of the largest online repositories for human and mouse stem cell gene expression data, StemBase was first designed as a simple web-interface to DNA microarray data generated by the Canadian Stem Cell Network to facilitate the discovery of gene functions relevant to stem cell control and differentiation. The majority of gene expression data are derived from Affymetrix GeneChip(R) DNA microarrays (Table 1; the complete up to date list is online at http://www.stem base.ca/?path=/browse/experiments). In addition to microarray experiments, StemBase contains data from six SAGE libraries, which correspond to differentiated and undifferentiated stages of three murine stem cell lineages.
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