Abstract
Hirschsprung's disease(HD) is a conginental disorder of enteric nervous system(ENS) and is associated with the abnormal migration of gut neural cerst cell(GNCC). Recent studies showed that the regulation of this migration is a complex gene network.By the development of epigenetic and stem cells, this network is becoming much more clear.Transplantation of the modified gut neural crest stem cells/gut neural crest precursors(GNCSC/GNCP) acquired from the HD bowl is becoming the potential therapy of HD.This paper summerizes the recent advances and is to promote better understanding the pathogenesis of HD. Key words: Hirschsprung's Disease; Pathogenesis; Gene network; Development
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