Abstract
Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PDA is restricted because of the low drug-loading and encapsulation efficiencies of hydrophobic drugs. Nevertheless, the emergence of mesoporous materials broaden our horizon. Mesoporous polydopamine (MPDA) has the characteristics of a porous structure, simple preparation process, low cost, high specific surface area, high light-to-heat conversion efficiency, and excellent biocompatibility, and therefore has gained considerable interest. This review provides an overview of the preparation methods and the latest applications of MPDA-based nanodrug delivery systems (chemotherapy combined with radiotherapy, photothermal therapy combined with chemotherapy, photothermal therapy combined with immunotherapy, photothermal therapy combined with photodynamic/chemodynamic therapy, and cancer theranostics). This review is expected to shed light on the multi-strategy antitumor therapy applications of MPDA-based nanodrug delivery systems.Graphical
Highlights
Cancer is the second-leading cause of mortality worldwide, with increasing number of deaths and incidences
CP@ mPDA (CPP) was modified with hyaluronic acid (HA) through electrostatic adsorption, and the anticancer drug DOX was loaded by π-π stacking to obtain CuO2@mPDA/DOXHA (CPPDH) multifunctional nano-platform integrating Chemodynamic therapy (CDT), photothermal therapy (PTT), and chemotherapy, which could induce the depletion of glutathione (GSH) and self-supply of H2O2. CuO2 nanodots were triggered by the acidic tumor microenvironment (TME) to produce a large amount of Cu2+ and H2O2
The results showed that compared with other preparations, Mesoporous polydopamine (MPDA)@superparamagnetic iron oxide (SPIO)/sialic acid (SA)-PEI/ AFP-ferritin heavy chain (Fth) had better ability to enhance Magnetic resonance imaging (MRI) contrast of T2-weighted images in tumor region, and could be used as an effective MRI contrast agent for early detection of hepatocellular carcinoma (HCC)
Summary
Cancer is the second-leading cause of mortality worldwide, with increasing number of deaths and incidences. Tang et al developed a preparation procedure for mesoporous carbon material using high-molecular-weight block copolymers as templates and successfully synthesized mesoporous polydopamine (MPDA), which enhanced the research potential of PDA [52]. This MPDA-based nano-platform provides ideas for the development of technologies for combination cancer treatments.
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