Abstract
Neutropenia and its associated bacterial and fungal infections are major limiting factors in the treatment of patients with aggressive chemotherapy regimens and hematopoietic stem cell transplantation. Although transfusion support with functional neutrophils is a logical approach to this clinical problem, such therapy has fallen out of favor over the last 10–15 years, at least in part because clinicians have not found the results impressive. This apparent lack of efficacy has been largely attributed to the relatively low doses of granulocytes obtainable by conventional collection techniques. An additional problem is that granulocytes obtained for transfusion rapidly undergo apoptosis, resulting in an inability to store the cells and limited survival in the recipient.
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