Abstract
Within the wide range of nitrogen-containing heterocyclic compounds, the derivatives of 1,8-naphthyridine (NPTR) have gained a rising interest due to their reported versatile biological activities. The derivatives of NPTR scaffold are found to invite special interest from researchers nowadays on the significance of their manifestations of multiple attractive pharmacological activities which establish them as an effective and versatile tool in pharmaceutical chemistry and drug discovery. The diverse biological activities mainly include anti-inflammatory, antimicrobial, antiviral, anticancer, antihypertensive and analgesic activities. Novel NPTR scaffold has emerged its potency to treat neurological diseases like depression and Alzheimer's disease. Further these agents possess different inhibitory activities, such as anti-HIV, anti-osteoporotic, αvβ3 antagonism, antimalarial, platelet aggregation, anti-oxidant, anti-allergic, gastric antisecretory, anticonvulsant, epidermal growth factor receptor (EGFR) inhibition, protein kinase inhibition, ionotropic properties, β3 antagonism, phosphodiesterase 4 (PDE 4) inhibitions, adenosine receptor agonistic activity, adrenoceptors antagonism and DNA stabilizing activity, etc. In this review, we highlight the updates of different 1,8-naphthyridine derivatives and explain the key data available in the context of various biological activities of NPTR derivatives available from the literature. This may direct opportunity in researches in the synthesis of novel medicinal agents and the development of new heterocycles for modification of existing biological actions as well as evaluation of other possible pharmacological activities.
Highlights
Nowadays, researchers are concentrating interests towards the introduction of novel and safe therapeutic agents for getting medical significance [1]
Amongst the six isomeric pyridopyridines, the derivative having 1, 8naphthyridine (NPTR) ring gained the importance in the last 25 y. This group of derivatives has drawn interests mainly owing to the NPTR ring system which is abundant in lots of active derivatives including inherent substances and possesses different biological behavior
The results indicate that [[18] F] cannabinoid-1 receptor (CB1) is a potential candidate marker for distribution of CB2 receptor
Summary
Researchers are concentrating interests towards the introduction of novel and safe therapeutic agents for getting medical significance [1]. The name naphthyridine is often known to the fused-ring system, which is formed by the fusion of two pyridine rings with two neighboring carbon atoms, and every ring system having only a single nitrogen atom. Amongst the six isomeric pyridopyridines, the derivative having 1, 8naphthyridine (NPTR) ring gained the importance in the last 25 y This group of derivatives has drawn interests mainly owing to the NPTR ring system which is abundant in lots of active derivatives including inherent substances and possesses different biological behavior. The quantity of publications and patents related to the chemical and biological activities of 1, 8-naphthyridines derivatives which were issued and published during this era is more than the number of research on other pyridopyridines in the previous more than 90 y. 1,8-Naphthyridine derivatives and their use to treat diabetes and related disorders
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