Recent Development on Spectroscopic Methods for Chiral Analysis of Enantiomeric Compounds

Abstract

Chirality has become a central theme in scientific research and is an important task in the field of analytical chemistry. In the past few decades, demand for chiral recognition and separation has increased due to the importance of chirality in many fields such as pharmaceutics, chemical industry, agriculture, and biological and clinical analysis. A survey of the literature suggests that different spectroscopic methods are applied to achieve the analysis of chiral enantiomeric compounds. This article is intended to focus on chiral analysis and affords a brief overview on chiral analysis of enantiomeric compounds using different spectroscopic methods, such as fluorescence spectroscopy, mass spectrometry, and nuclear magnetic resonance spectroscopy. In this review, primarily the intensive studies of how chiral recognition is achieved and an updated view of the different strategies used up to recognize the chirality of enantiomeric compounds are discussed.