Abstract
Heterogeneity of meroterpenoids arising from their dual biosynthetic origins is constantly provoking synthetic chemists to utilize their ingenuity and revise their retrosynthetic logic. By studying recent publications on meroterpenoid synthesis, tremendous advances in the field of synthetic organic chemistry can be witnessed. This minireview covers some of the most intriguing total syntheses and synthetic studies towards the meroterpenoid class of natural products from the last five years.
Highlights
Heterogeneity of meroterpenoids arising from their dual biosynthetic origins is constantly provoking synthetic chemists to utilize their ingenuity and revise their retrosynthetic logic
Meroterpenoids represent a family of natural products that originate from the combination of the Greek word meros, meaning part, and terpenoids, which are natural isoprene-derived compounds
Numerous new meroterpenoids are isolated each year from natural sources, which requires the employment and advancement of modern synthetic organic chemistry to effectively obtain sufficient quantities of newly isolated meroterpenoids for more detailed studies
Summary
Meroterpenoids represent a family of natural products that originate from the combination of the Greek word meros, meaning part, and terpenoids, which are natural isoprene-derived compounds. Their structural diversity stems from their hybrid terpenoid and polyketide biosynthetic roots. The purpose of this review is to highlight the most efficient modern chemical tools and strategies that have been developed to access different classes of meroterpenoids since 2015. A more specific review on biosynthesis as well as chemical synthesis of fungal meroterpenoids breviones has been published by Macías.[4] a conceptionally similar survey on meroterpenoids from Streptomyces bacteria has been disclosed earlier this year jointly by Moore and George.[5] In contrast, other reviews focus exclusively on synthetic efforts toward specific classes of meroterpenoids. The aforementioned topics will be omitted from this feature article
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