Abstract
Organocatalysis has emerged as one of the most important tools for the synthesis of diverse structural scaffolds, and has become one of the most important hot topics of current research. Construction of the pyrrole ring has gained much attention from the last few decades due to its remarkable biological activities, pharmaceutical application, intermediate in the synthesis of many natural products, and material science application. With access to these 5-membered aza heterocycles, organocatalytic approaches have provided a new alternative from the perspective of synthetic efficiency, as well as from the green chemistry point of view, and a vast array of synthetic procedures has been developed. Enlightened by the significance of this growing research area, we aim to describe the recent organocatalytic approaches developed for the construction of pyrroles, and organized them based on substrates employed.
Highlights
Pyrroles are the most well-known ve-membered nitrogencontaining heterocyclic aromatic compounds, and are the key structural unit of heme and related porphinoid co-factors,[1] such as heme b, chlorophyll a, vitamin B12, and factor 430
Biplob Borah was born in 1995 in Garukhunda, a small village in the Nagaon District of Assam, India. He graduated with a BSc degree in Chemistry from Nowgong College (Gauhati University), Assam in 2017, and received his Master's degree in Industrial Chemistry from the Central University of Gujarat, India in 2019. He has joined as a PhD Scholar in the School of Applied Material Science at the Central University of Gujarat under the guidance of Dr L
Several reviews have covered the synthesis of pyrroles based on multicomponent reactions,[15] metal-catalyzed syntheses,[16] and others,[17] the organocatalytic approaches toward its synthesis have not been covered with all details until now. This current review aims to provide access to the works on the synthesis of pyrroles by using various organocatalytic strategies and their development to the
Summary
Pyrroles are the most well-known ve-membered nitrogencontaining heterocyclic aromatic compounds, and are the key structural unit of heme and related porphinoid co-factors,[1] such as heme b, chlorophyll a, vitamin B12, and factor 430. Biplob Borah was born in 1995 in Garukhunda, a small village in the Nagaon District of Assam, India He graduated with a BSc degree in Chemistry from Nowgong College (Gauhati University), Assam in 2017, and received his Master's degree in Industrial Chemistry from the Central University of Gujarat, India in 2019. Kartikey Dhar Dwivedi was born in 1992 in Barouhin, a small village in the Rewa District of Madhya Pradesh, India He obtained his BSc degree from Swami Sharddhanand College (Delhi University), Delhi in 2014, and MSc degree in Chemistry from the Central University of Punjab, Bathinda, India in 2017. Raju Chowhan obtained his BSc degree from Osmania University, Master's degree from Hyderabad Central University, Hyderabad, and PhD from the CSIR-Indian Institute of Chemical Technology, in association with Hyderabad Central University He joined as an Assistant Professor in the Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar in September 2012. On behalf of the appropriate understanding and a convenient presentation, the article is classi ed according to the nature of the substrates used
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