Abstract
Due to their selectivity and chemical stability, molecularly imprinted polymers have attracted great interest in sample preparation. Imprinted polymers have been applied for the extraction and the enrichment of different sorts of trace analytes in biological and environmental samples before their analysis. Additionally, MIPs are utilized in various sample preparation techniques such as SPE, SPME, SBSE and MEPS. Nevertheless, molecularly imprinted polymers suffer from thermal (stable only up to 150 °C) and mechanical stability issues, improper porosity and poor capacity. The sol-gel methodology as a promising alternative to address these limitations allowing the production of sorbents with controlled porosity and higher surface area. Thus the combination of molecularly imprinted technology and sol-gel technology can create influential materials with high selectivity, high capacity and high thermal stability. This work aims to present an overview of molecularly imprinted sol-gel polymerization methods and their applications in analytical and bioanalytical fields.
Highlights
Imprinted polymers (MIPs) as a privileged sorbent provide selective recognition sites for a template molecule of interest based on its size, structure and functional groups
In situ monolithic in-tip Molecularly imprinted polymers (MIPs) made by the sol-gel process are an easy, fast, robust and durable method that has been applied for the selective extraction process are an easy, fast, robust and durable method that has been applied for the selective extraction of l-tyrosine (Tyr), a potential lung cancer biomarker, from biological fluids [43]
Solution to the surface is a key factor in Hollow fibers (HFs) performance which can be facilitated using solution modified sorts of HFs are mostly applied in the liquid-phase microextraction (LPME) field [45]
Summary
Imprinted polymers (MIPs) as a privileged sorbent provide selective recognition sites for a template molecule of interest based on its size, structure and functional groups. In this phosphates and phosphonates from aqueous samples and it was a great starting point for further review we briefly coverfield the most recent methods and their applications developments in this [20] Diethyl-stilbestrol is a harmful residue to human health due to its potential carcinogenicity and in an important study it was extracted in milk samples by a magnetic MIP which was synthesized using a combination of bulk and sol-gel techniques [37]. The most problematic issue in MSG preparation is the leakage of template molecule, especially in the extraction of trace analytes in complex media To overcome this problem the dummy silica MSG nanospheres method was presented by Liu for SPE of bisphenol A in food samples [38].
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