Abstract
Activated cyclopropanes show versatile reactivity and are therefore powerful building blocks in organic chemistry and natural product synthesis. This review focuses on recent applications of cyclopropane-based approaches to the syntheses of natural products. These applications include diverse processes involving cyclopropanation–ring-opening–cyclization or ring expansion to form key natural product skeletons. 1 Introduction 2 Formal Cycloaddition Strategies 2.1 Formal [3+2] Cycloaddition with Aldehydes and Ketones 2.2 Formal [4+3] Cycloaddition via Cope Rearrangement 2.3 Cycloaddition with Transition Metals 3 Cyclopropanation–Ring-Opening Strategies 4 Cyclopropanation–Ring-Opening–Cyclization Strategies 5 Ring Closing via Cyclopropanation 6 Conclusion
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