Recent Advances Towards Point-Of-Care Applications of Surface-Enhanced Raman Scattering Sensing.

Steven Quarin,Pietro Strobbia

doi:10.3389/fchem.2021.714113

Abstract

The ability to accurately diagnose at the point of care is crucial in many pathologies. However, current standard diagnostic practices can only be performed in specialized health or laboratory settings. To move diagnostic methods from a specialized lab to the point of care many alternate methods have been developed and proposed. Among them surface-enhanced Raman scattering (SERS) sensing offers advantageous features, such as simultaneous detection of multiple biotargets and increased accuracy. Many groups have been working towards the translation of SERS sensing methods from the lab to the point of need. In this mini review, we discuss interesting and recent developments in this effort, focusing on how different sensing mechanism can be used in point-of-care testing applications of SERS.

Highlights

The ability for accurately point-of-care (POC) diagnosis is crucial for many diseases to ensure early intervention and/or reduce the disease spread
The amplification arises from the localized surface plasmon resonance, a collective oscillation of conductive band electrons produced by the interaction with light at a specific wavelength (Moskovits, 2005)
The detection was performed on RNA extracted directly from tissue samples collected during surgery and the results showed a high diagnostic accuracy for squamous cell carcinoma (SCC) diagnosis, without the need for any target amplification

Summary

Steven Quarin and Pietro Strobbia *

The ability to accurately diagnose at the point of care is crucial in many pathologies. To move diagnostic methods from a specialized lab to the point of care many alternate methods have been developed and proposed. Among them surface-enhanced Raman scattering (SERS) sensing offers advantageous features, such as simultaneous detection of multiple biotargets and increased accuracy. Many groups have been working towards the translation of SERS sensing methods from the lab to the point of need. In this mini review, we discuss interesting and recent developments in this effort, focusing on how different sensing mechanism can be used in point-of-care testing applications of SERS

INTRODUCTION

DISCUSSION

CONCLUSION AND PERSPECTIVES

Immunoassay of the PSA Cancer Marker Using SERS and Droplet