Abstract
Conia-ene reactions, as a type of ene reactions, have not become a remarkable focus until the beginning of 21st century, when Lewis acids served as powerful catalysts and found an increasingly broad utilization in this field. Consequently, the catalytic Conia-ene reactions have gained great significance in synthetic chemistry due to their high efficiency and atom economy on the construction of valuable cyclic molecules. During the past two decades, the rapid development of transition-metal catalysis and organocatalysis has imposed a profound impact on the exploration of asymmetric Conia-ene reactions. As a result, several strategies have been developed and applied successfully. Organized on the basis of the catalytic system, this review comprehensively presents a summary of recent progress achieved in this emerging domain, aimed at highlighting the reactions’ features, practicalities, and the mechanistic rationale is presented where possible.
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