Abstract
AbstractDibenzoxepines have gained privileged status in medicinal chemistry and drug discovery due to their appearance in various natural products and life-saving drug molecules. Dibenzoxepine-based molecules, such as artocarpols, asenapine, and pacharin, possess a wide range of biological activities including anti-inflammatory, antidepressant, antihypertensive, antiestrogenic, and insecticidal activities. Therefore, designing and developing new methodologies to access the dibenzoxepine core has become a paramount research topic for organic/ medicinal chemists. Herein, we reviewed various synthetic methods to access dibenzoxepine derivatives. The total syntheses of dibenzoxepine-based natural products and biologically/medicinally important molecules have also been reviewed.1 Introduction2 Transition-Metal-Free Approaches2.1 Acid-Mediated Transformations2.2 Base-Mediated Transformations2.3 NHC-Organocatalyzed Transformations2.4 Miscellaneous3 Metal-Mediated Approaches4 Transition-Metal-Catalyzed Approaches4.1 Iron-Catalyzed Transformations4.2 Copper-Catalyzed Transformations4.3 Ruthenium-Catalyzed Transformations4.4 Palladium-Catalyzed Transformations4.5 Other Transition-Metal-Catalyzed Transformations5 Total Syntheses6 Conclusion
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