Recent Advances on the Development of Synthetic Strategies to Access Dibenzoxepine Derivatives

Abstract

AbstractDibenzoxepines have gained privileged status in medicinal chemistry and drug discovery due to their appearance in various natural products and life-saving drug molecules. Dibenzoxepine-based molecules, such as artocarpols, asenapine, and pacharin, possess a wide range of biological activities including anti-inflammatory, antidepressant, antihypertensive, antiestrogenic, and insecticidal activities. Therefore, designing and developing new methodologies to access the dibenzoxepine­ core has become a paramount research topic for organic/ medicinal chemists. Herein, we reviewed various synthetic methods to access dibenzoxepine derivatives. The total syntheses of dibenzoxepine-based natural products and biologically/medicinally important molecules have also been reviewed.1 Introduction2 Transition-Metal-Free Approaches2.1 Acid-Mediated Transformations2.2 Base-Mediated Transformations2.3 NHC-Organocatalyzed Transformations2.4 Miscellaneous3 Metal-Mediated Approaches4 Transition-Metal-Catalyzed Approaches4.1 Iron-Catalyzed Transformations4.2 Copper-Catalyzed Transformations4.3 Ruthenium-Catalyzed Transformations4.4 Palladium-Catalyzed Transformations4.5 Other Transition-Metal-Catalyzed Transformations5 Total Syntheses6 Conclusion