Abstract
The Pd/C-catalyzed reactions, including reduction reactions and cross-coupling reactions, play an irreplaceable role in modern organic synthesis. Compared to the homogeneous palladium catalyst system, the heterogeneous Pd/C catalyst system offers an alternative protocol that has particular advantages and applications. Herein, a review on Pd/C-catalyzed reactions is presented. Both the advances in Pd/C-catalyzed methodologies and the application of Pd/C-catalysis in total synthesis are covered in this review.
Highlights
Palladium-catalyzed organic reactions are a fundamental tool of modern organic synthesis
Several reviews on palladium on carbon (Pd/C)-catalyzed reactions have already been published in the last fifteen years [3,4,8,10], in this review, we examined recent advances in the chemistry of Pd/C-catalyzed reactions, such as reduction reactions and cross-coupling reactions, because these reactions are widely used for organic synthesis, and they provide a guiding principle for designing the route to be used by organic chemists
Nitta et al made an important contribution to the enantioselective hydrogenation of α-phenylcinnamic acid (15,16) (PCA) on cinchonidine-modified palladium catalysts, and several publications on the asymmetric catalysis of this α,β-unsaturated carboxylic acid (Scheme 4), which is a kind of chiral compound with wide applications, were published
Summary
Repeated filtration processes are possible due to their high stability, so the Pd/C can be recycled and reused with little loss of activity. Their high tolerance to strong acids or bases, air, and moisture makes Pd/C catalysts suitable for a variety of reactions under moderate or harsh conditions [3,4]. Due to these advantages, Pd/C catalysts have attracted much attention in recent laboratory research, but are becoming increasingly popular in industrial production.
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