Abstract
Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes with thiols, represents one of the most efficient and atom-economic approaches for the carbon-sulfur bonds construction. In traditional methodologies, harsh conditions such as stoichiometric reagents or a specialized UV photo-apparatus were necessary suffering from various disadvantages. In particular, visible-light photoredox catalysis has also been demonstrated to be a greener and milder protocol for the thiol-ene/yne reactions in recent years. Additionally, unprecedented advancements have been achieved in this area during the past decade. In this review, we will summarize the recent advances in visible-light photoredox catalyzed thiol-ene/yne reactions from 2015 to 2021. Synthetic strategies, substrate scope, and proposed reaction pathways are mainly discussed.
Highlights
SelectedExamples of the visible‐light ene/yne reactions that were applied in the field of biology and materials will be ignored in photocatalytic thiol‐ene/yne reactions that were applied in the field of biology and photocatalytic thiol‐ene/yne reactions that were applied in the field of biology and this article; we will mainly focus our attention on the literatures involving the development materials will be ignored in this article; we will mainly focus our attention on the materials will be ignored in this article; we will mainly focus our attention on the of syntheticinvolving methodologies for thiol-ene/yne reactions.methodologies
Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades
Examples of the visible‐light ene/yne reactions that were applied in the field of biology and materials will be ignored in photocatalytic thiol‐ene/yne reactions that were applied in the field of biology and photocatalytic thiol‐ene/yne reactions that were applied in the field of biology and this article; we will mainly focus our attention on the literatures involving the development materials will be ignored in this article; we will mainly focus our attention on the materials will be ignored in this article; we will mainly focus our attention on the of syntheticinvolving methodologies for thiol-ene/yne reactions.methodologies
Summary
Examples of the visible‐light ene/yne reactions that were applied in the field of biology and materials will be ignored in photocatalytic thiol‐ene/yne reactions that were applied in the field of biology and photocatalytic thiol‐ene/yne reactions that were applied in the field of biology and this article; we will mainly focus our attention on the literatures involving the development materials will be ignored in this article; we will mainly focus our attention on the materials will be ignored in this article; we will mainly focus our attention on the of syntheticinvolving methodologies for thiol-ene/yne reactions.methodologies. Due to the high reactivity of sulfur, the thiol-ene/yne reactions tend to proceed via a radical pathway to provide the anti-Markovnikov products by visible-light photoredox catalysis. Since Yoon and Stephenson’s pioneering works, various photocatalytic systems with anti-Markovnikov selectivity have been reported for synthesis of the diversity of organosulfur compounds. Photocatalytic Anti‐Markovnikov Thiol‐Ene Reactions for Synthesis of Alkyl Thioethers
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