Abstract
Visible-light photoredox catalysis has attracted tremendous interest within the synthetic community. As such, the activation mode potentially provides a more sustainable and efficient platform for the activation of organic molecules, enabling the invention of many controlled radical-involved reactions under mild conditions. In this context, amide synthesis via the strategy of photoredox catalysis has received growing interest due to the ubiquitous presence of this structural motif in numerous natural products, pharmaceuticals and functionalized materials. Employing this strategy, a wide variety of amides can be prepared effectively from halides, arenes and even alkanes under irradiation of visible light. These methods provide a robust alternative to well-established strategies for amide synthesis that involve condensation between a carboxylic acid and amine mediated by a stoichiometric activating agent. In this review, the representative progresses made on the synthesis of amides through visible light-mediated radical reactions are summarized.
Highlights
N-chloro-N-sodio carbamates under tocatalytically generated from the initially photostable N-chloro-N-sodio carbamates unirradiation of blue LEDs, could activate aldehydes to further enable amide synthesis der irradiation of blue LEDs, could activate aldehydes to further enable amide synthesis (Figure 36) [93,94]
Over the past few years, visible-light-driven photoredox catalysis has in organic synthesis
We summarized the recent representative examples in field of visible-light-mediated this review, we summarized the recent representative examples in field of visible-lightamide construction, which were discussed according to different catalytic modes andcatalytic radical mediated amide construction, which were discussed according to different precursors
Summary
Visible light is an inexhaustible energy source with environmentally friendly characteristics. Visible-light-mediated radical reactions can usually break and recombine chemical bonds under milder and more sustainable conditions, which provides new platforms for the formation of chemical bonds in a controlled manner. Given these advantages, over the past years, photoredox catalysis has emerged as a valuable synthetic tool in synthetic organic chemistry [18,19,20,21,22,23,24,25,26,27,28,29].
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