Abstract
FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.
Highlights
The Forkhead proteins (FOX) belongs to a subgroup of “helical-fold-helical” proteins [1]
This study showed that forkhead box N3 (FOXN3) can inhibit the progression of the colon cancer, and that restoration of the function of FOXN3 is expected to become a novel therapeutic strategy for the colon cancer [71]
FOXN3 is mostly down-regulated in most solid tumors and hematological malignancies, and up-regulated in only a small number of diseases
Summary
The Forkhead proteins (FOX) belongs to a subgroup of “helical-fold-helical” proteins [1]. ChIP-Seq experiments found that the FOXN3-NEAT1-SIN3A complex suppressed a group of genes, including GATA3 and TJP1 (genes regulating cell maintenance and differentiation).
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