Abstract
Abstract Organofluorine compounds are widely found in pharmaceuticals, agrochemicals, and materials due to their special properties. However, development of transformations to incorporate fluorine atom is usually a great challenge, because of its highly electronegative nature. Transition-metal catalyzed C—H bond fluorination has significant advantages in atom-economy, reaction diversity and environmental friendliness in comparison with the traditional transition-metal catalyzed cross-coupling approaches since it obviates the use of pre-functionalized substrates. In the past decade, C—H bond fluorination strategy has emerged as a powerful protocol to access new C—F bonds. This review presents the state of art for transition-metal catalyzed C—H bond fluorination. The existing problems and limitations of the field are summarized and the outlook of the area is also prospected.
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