Recent Advances in Transition-Metal-Catalyzed Iodination of Arenes

Abstract

Aryl and heteroaryl iodides are ubiquitous synthetic building blocks used in a wide range of transformations including coupling and radical reactions. These compounds are also found as components of many pharmaceutically active agents and used for medical imaging. Due to their importance, a range of transition-metal-catalyzed methods have recently been developed for their efficient preparation. This short review gives an overview of the progress made and highlights the benefits of transition-metal-catalyzed methods over more traditional approaches. 1 Introduction 2 Halogen-Exchange Reactions 3 Copper-Catalyzed Iodination Using Boronic Acids and Esters 4 Electrophilic Aromatic Substitution 4.1 Gold-Catalyzed Reactions 4.2 Indium-, Iron-, and Silver-Catalyzed Reactions 5 Iodination via C–H Activation 5.1 Palladium-Catalyzed Reactions 5.2 Rhodium-, Ruthenium-, and Cobalt-Catalyzed Reactions 5.3 Copper-Catalyzed Reactions 6 Iododecarboxylation 7 Conclusions