Recent Advances in the Synthesis of Thiadiazoles

Abstract

Thiadiazole moieties are present in many natural products and pharmaceutical compounds that possess a broad spectrum of biological activities, serving as antidepressant, anxiolytic, antimicrobial, antitubercular, antiinflammatory, antidiabetic, anticancer, antihypertensive, or antifungal drugs. Many excellent methods have been reported for accessing such frameworks. In this review, we summarize advances made within the past ten years in the synthesis of various types of thiadiazole.1 Introduction2 Synthesis of Thiadiazoles2.1 Synthesis of 1,2,3-Thiadiazoles2.1.1 Synthesis of 1,2,3-Thiadiazoles from Diazo/Azide Compounds2.1.2 Synthesis of 1,2,3-Thiadiazoles from Sulfonyl Hydrazines or N-Tosylhydrazones2.2 Synthesis of 1,2,4-Thiadiazoles2.2.1 Synthesis of 1,2,4-Thiadiazoles from Thioamides or their Derivatives2.2.2 Synthesis of 1,2,4-Thiadiazoles from Amidines or 2-Aminopyridines2.3 Synthesis of 1,3,4-Thiadiazoles2.4 Synthesis of 1,2,5-Thiadiazoles3 Conclusion