Abstract
Chapter 19 covers the recent advances in the synthesis of α-hydroxy-β-amino acids and their use in the medicinal chemistry as well as chemical biology of taxoid anticancer agents, including: Synthesis of enantiopure α-hydroxy-β-amino acid components of taxane anticancer agents by β-lactam synthon method New C-13 α-hydroxy-β-amino acid residues and their significance in the second generation taxoids Taxoids with photoaffinity labeling α-hydroxy-β-amino acid residues Taxoids with fluorine- and isotope-labeled α-hydroxy-β-amino acid residues for NMR studies
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