Abstract
This chapter documents the synthetic development in the field of dendrobatid alkaloids accumulated during 1990s under six sub-divisions: 2,5-Disubstituted decahydroquinoline alkaloids, histrionicotoxins, indolizidine alkaloids, pumiliotoxin A class alkaloids, epibatidine, and miscellaneous. The unusual chemical and neuromuscular characteristics have prompted chemists to develop numerous approaches to non-chiral and chiral syntheses of the 2,5-disubstituted decahydroquinoline alkaloids mainly pumiliotoxin C. 5-Substituted 8-methylindolizidines occur in a wide range of dendrobatid species and represent one of the many classes of dendrobatid alkaloids. The absolute configuration of the natural epibatidine is determined by the comparison of synthetic material with authentic material by using chiral High Performance Liquid Chromatography (HPLC) and by using X-ray crystallography by the Merck group.
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